TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)

TRMT1 (hTRM1) transfers two methyl groups from two molecules of S-adenosylmethionine to the 2 position of guanosine-26 of tRNA(Tyr), yielding 2-dimethylguanosine (Liu and Straby 2000). TRMT1 can dimethylate both spliced and unspliced tRNA (Liu and Straby 2000).

TRMT1（hTRM1）能够从两分子S-腺苷甲硫氨酸中转移两个甲基至tRNA(Tyr)的鸟嘌呤-26位，从而生成2-二甲基鸟苷（刘与斯特雷比，2000年）。TRMT1能够对已剪接和未剪接的tRNA进行二甲基化处理（刘与斯特雷比，2000年）。