Exploring of gut microbiota features in dyslipidemia and chronic coronary syndrome patients undergoing coronary angiography

Chronic coronary syndrome (CCS) has a high mortality rate, and dyslipidemia is a major risk factor. Atherosclerosis, a cause of CCS, is influenced by gut microbiota dysbiosis and its metabolites. We aimed to study the diversity and composition of gut microbiota and related clinical parameters in CCS patients undergoing coronary angiography and dyslipidemia patients compared to healthy volunteers in Thailand. We reported on 91 patients and found that CCS patients had more risk factors and higher inflammatory marker, high-sensitivity C-reactive protein (hs-CRP)) than others. The alpha diversity was lower in dyslipidemia and CCS patients than in those healthy. A significant difference in the composition of gut microbiota was observed among the three groups. The relative abundance of Proteobacteria, Fusobacteria, Enterobacteriaceae, Prevotella and Streptococcus were significantly increased while Roseburia, Ruminococcus and Faecalibacterium were lower in CCS patients. In CCS patients, Lachnospiraceae, Peptostreptococcaceae and Pediococcus were positively correlated with hs-CRP. In dyslipidemia patients, Megasphaera was strongly positively correlated with TG level and negatively correlated with HDL-C. Modification of gut microbiota is associated with changes in clinical parameters involved in the development of CAD in CCS patients.