AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via limiting CXCL2-mediated neutrophil infiltration

We aimed to investigate the strategies to protect against pancreatitis severity and we focused on AXL and MERTK tyrosine kinases receptors, which are the negative regulator of the innate immune response. In order to investigate the underlying mechanism of AXL and MERTK in mediating pancreatic necrosis, we performed high-throughput mRNA sequencing on the pancreatic tissues of 6 C57BL/6J wild type mice and 6 Axl-/-Mertk-/- mice under hyperstimulation of caerulein. Pancreas were collected from caerulein-treated C57BL/6J wild type mice and Axl-/-Mertk-/- mice. Total RNA from pancreatic tissue was processed for RNAsequencing.