Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis

The repository contains the processed Seurat object generated from SELECT-seq data of ESAT-6/CFP-10-specific T cells sorted from PBMC of household contacts of sputum culture-positive cases of pulmonary TB (four subjects with latent TB infection (LTBI) and three M. tuberculosis 'resisters' (RSTR)).

Information on how the Seurat object was analyzed can be found in this GitHub respository: https://github.com/ttsunmeng/TB_RSTR_ESAT6CFP10_SelectSeq_analysis_pipeline.

The full details of this cohort have been previously published here:

Stein, C.M., et al. Long-term Stability of Resistance to Latent Mycobacterium tuberculosis Infection in Highly Exposed Tuberculosis Household Contacts in Kampala, Uganda. Clin Infect Dis 68, 1705-1712 (2019).

Stein, C.M., et al. Resistance and Susceptibility to Mycobacterium tuberculosis Infection and Disease in Tuberculosis Households in Kampala, Uganda. Am J Epidemiol 187, 1477-1489 (2018).