A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients. A longitudinal and transancestral analysis of DNA methylation patterns and disease activity in lupus patients

Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a longitudinal analysis to assess changes in DNA methylation in neutrophils collected from 54 lupus patients over 4 years of follow up and across disease activity levels using 229 patient samples. Overall design: Illumina Infinium MethylationEPIC array of genomic DNA from neutrophils extracted from whole blood from 54 systemic lupus erythematosus (SLE) patients over time for a total of 229 timepoints.