m6A methyltransferase METTL3 programs CD4+ T cell activation and regulatory T cell differentiation in SLE

To investigate the function of METTL3 in the regulation of Treg cell differentiation, we treated inducd Tregs with STM2457 in which the catalytic activity of METTL3 has been phrmacologically inhibited. We then performed gene expression profiling analysis using data obtained from RNA-seq of 8 different cells at one time point. Comparative gene expression profiling analysis of RNA-seq data for induced Treg cells and its METTL3-inhibitory derivatives.