IL-13Ra1-mediated signaling regulates ABC expansion and lupus pathogenesis

ABCs are an emerging B cell subset that aberrantly expand in SLE. ABC generation and differentiation exhibit marked sexual dimorphism and TLR7 engagement is a key contributor to these sex differences. ABC generation is also controlled by IL-21 and its interplay with IFNg and IL-4. Here we investigated whether IL-13Ra1, an X-linked receptor that transmits IL-4/IL-13 signals, can regulate ABCs and lupus pathogenesis. Overall design: 7 samples: 4 DKO, 3 IL13KO+DKO contributor: HSS Genomics Research Center