An essential role for dNTP homeostasis following CDK-induced replication stress

ChEBI2018-10-31 更新2026-07-12 收录

DNA复制应激

核苷酸代谢调控

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An essential role for dNTP homeostasis following CDK-induced replication stress

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2018-10-31

Data_Sheet_1_Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli.PDF

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核苷酸代谢调控

Stringent response mediated by modified guanosine nucleotides is conserved across bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT proteins synthesize the mo

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Erk5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis

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血细胞发育异常

An adequate supply of nucleotides is essential for accurate DNA replication, and inappropriate deoxyribonucleotide triphosphate (dNTP) concentrations can lead to replication stress, a common source of

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Cohesin maintains replication timing to suppress DNA damage on cancer genes [MCM5_ChIPseq]

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基因组不稳定性

Cohesin loss-of-function mutations are frequently observed in tumors, but the mechanism is unclear. Here, we found that depletion of RAD21, a core subunit of cohesin, leads to massive genome-wide DNA

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Effect of AICAR and SAICAR accumulation on global transcription (first part). Saccharomyces cerevisiae

核苷酸代谢调控

转录组学分析

We investigated the effects of AICAR and SAICAR accumulation on transcriptional regulation of purine biosynthesis and other metabolic pathways. In this work, global transcription analyses were combine

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Numerical data used for the generation of graphs.

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基因组稳定性

Replication stress threatens genome integrity by exposing replication forks to nucleolytic degradation. In both yeast and humans, the checkpoint kinases Mec1 and Rad53 limit deleterious single-strande

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An essential role for dNTP homeostasis following CDK-induced replication stress

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