HSP90 MIND-S Model

HSP90 is at the hub of proteostasis and cellular signaling networks in cancer. Post-translational modification (PTM) of proteins regulates cellular proteostasis by expanding protein functional diversity. This dataset contains the original code for a deep-learning artificial intelligence (AI) prediction model created to decipher PTM crosstalk on HSP90. Fine-tuning of the model was achieved using experimental mass-spectrometry data of wild type (WT) alpha and beta isoforms of HSP90, as well as variants carrying a specific lysine-to-glutamine (K→Q) mutation to capture potential PTM patterns across isoforms and mutation contexts.