Single-cell transcriptomic profiling reveals a metabolic aspect of non-apoptosis in inherited retinal degeneration

The aim of this study was to provide deeper insight into the complex network of molecular and cellular changes that underlie inherited retinal degeneration by systematically mapping the transcriptional changes that occur in the degenerating mouse retina. Rd1 and C3H wild type mice at different time points of P11(n = 3; Retina n = 6), P13 (n = 3; Retina n = 6) and P17 (n = 3; Retina n=6) were sacrificed regardless of gender for single cell RNA-sequencing (scRNA-seq) to profile the impact of rd1 mutation during mouse retina development.