Unique microRNA expression profiles in plasmic exosomes from intrahepatic cholestasis of pregnancy

Intrahepatic cholestasis of pregnancy (ICP) is strongly associated withan increased risk of adverse perinatal outcomes. Total bile acid (TBA) levels in the late second or third trimester are a major factor in the diagnosis. Here, we sought to establish the miRNA expression profile of plasma exosomes of ICP and identify possible biomarkers for the diagnosis of ICP. This case-control study involved 14 ICP patients as the experimental group and 14 healthy pregnant women as the control group. Among them, three ICP patients and three controls were used for isolation plasmic exosome and preliminary miRNA array analysis. The Agilent miRNA array was utilized to dynamically monitor the miRNA expression inplasmic exosomes of includedpatients in the first trimester(T1), second trimester(T2), third trimester (T3),and delivery (T4).