Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours.

Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours. Descriptor: (2S)-2-(4-{2-[1,3-BENZOXAZOL-2-YL(HEPTYL)AMINO]ETHYL}PHENOXY)-2-METHYLBUTANOIC ACID, Peroxisome proliferator-activated receptor gamma Authors: Pochetti, G, Mazza, F. Deposit date: 2006-08-23 Release date: 2007-04-17 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands J.Biol.Chem., 282, 2007过氧化物酶体增殖物激活受体γ（PPARγ，Peroxisome proliferator-activated receptor gamma）与部分激动剂LT127（脲基贝特衍生物）形成复合物的晶体结构。该结构源自浸泡6小时的晶体。配体标识：(2S)-2-(4-{2-[1,3-苯并恶唑-2-基(庚基)氨基]乙基}苯氧基)-2-甲基丁酸，对应受体为过氧化物酶体增殖物激活受体γ。作者：波切蒂（Pochetti, G）、马扎（Mazza, F）。提交日期：2006-08-23，发布日期：2007-04-17，末次修改日期：2023-08-30。解析方法：X射线衍射（分辨率2.25埃）。引用文献：《部分激动作用机制的新见解：过氧化物酶体增殖物激活受体γ配体结合域与两种对映体配体复合物的晶体结构》，《生物化学杂志》（J. Biol. Chem.），第282卷，2007年。