S.aureus TMK in complex with potent inhibitor compound 19, 2-(3-CHLOROPHENOXY)-3-FLUORO-4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]METHYL}BENZOIC ACID

Protein Data Bank Japan2024-02-28 更新2026-03-21 收录

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S.aureus TMK in complex with potent inhibitor compound 19, 2-(3-CHLOROPHENOXY)-3-FLUORO-4-{[(3S)-3-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)PIPERIDIN-1-YL]METHYL}BENZOIC ACID Descriptor: 2-(3-chlorophenoxy)-3-fluoro-4-{[(3S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl]methyl}benzoic acid, Thymidylate kinase Authors: Olivier, N.B. Deposit date: 2014-05-22 Release date: 2014-06-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Antibacterial inhibitors of gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region. J.Med.Chem., 57, 2014

与强效抑制剂化合物19——2-(3-氯苯氧基)-3-氟-4-{[(3S)-3-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)哌啶-1-基]甲基}苯甲酸——结合的金黄色葡萄球菌（Staphylococcus aureus）胸苷酸激酶（Thymidylate kinase, TMK）。描述项：2-(3-氯苯氧基)-3-氟-4-{[(3S)-3-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)哌啶-1-基]甲基}苯甲酸，胸苷酸激酶（Thymidylate kinase）。作者：Olivier, N.B.。提交日期：2014-05-22。发布日期：2014-06-11。最后修改日期：2024-02-28。实验方法：X射线衍射（1.94 Å）。引用文献：《革兰氏阳性菌胸苷酸激酶的抗菌抑制剂：新型疏水结合区域的构效关系与手性偏好》，《药物化学杂志》（J.Med.Chem.），第57卷，2014年

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2014-05-22