New Protocol-Guided Exploitation of a Lysosomal Sulfatase Inhibitor to Suppress Cell Growth in Glioblastoma Multiforme

Glioblastoma multiforme (GBM) is
a highly invasive and aggressive
malignant glioma. Current treatment modalities are unable to significantly
prolong survival in patients diagnosed with glioblastoma, so more
effective strategies of antitumor treatments are in urgent demand.
Here, we found that lysosomal sulfatase expression was significantly
correlated with poor prognosis of GBM. Hence, a new probe, MNG, was
developed with a new protocol utilizing glucose groups to detect lysosomal
sulfatase. It also exhibits potential for monitoring GBM cells, depending
on the hyperactive lysosomal sulfatase expression of tumor cells.
Meantime, we identified that sulbactam as the first reported lysosomal
sulfatase inhibitor inhibits the tumor growth of GBM. Collectively,
our work highlights that lysosomal sulfatase was detected using a
new protocol and its potential as a therapeutic target in GBM and
reveals a distinct mechanism that sulbactam inhibits cell proliferation
related to lysosomal sulfatase, indicating that sulbactam could be
a promising therapeutic agent against GBM.