Interaction between PHLDA1 and AURKA

PHLDA1 (TDAG51), the product of a gene involved in breast cancer progression, interacts with aurora kinase A (AURKA). While unphosphorylated PHLDA1 promotes AURKA ubiquitination and degradation, AURKA-mediated phosphorylation of PHLDA1 results in down-regulation of PHLDA1 protein levels. Ectopic expression of PHLDA1 strongly antagonizes AURKA-triggered oncogenic phenotypes, suggesting PHLDA1 downregulation as one of the key mechanisms by which AURKA promotes breast cancer (Johnson et al. 2011).

PHLDA1（TDAG51），一种参与乳腺癌进展的基因产物，与 Aurora 激酶 A（AURKA）相互作用。未磷酸化的 PHLDA1 促进 AURKA 的泛素化和降解，而 AURKA 介导的 PHLDA1 磷酸化则导致 PHLDA1 蛋白水平的下调。PHLDA1 的异位表达可强烈拮抗 AURKA 触发的致癌表型，这表明 PHLDA1 的下调是 AURKA 促进乳腺癌的关键机制之一（Johnson 等，2011 年）。