Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities

Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities Descriptor: 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE, Peroxisome proliferator-activated receptor gamma Authors: Lu, I.L, Peng, Y.H, Huang, C.F, Lin, Y.T, Hsu, J.T.A, Wu, S.Y. Deposit date: 2006-02-13 Release date: 2006-05-16 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.54 Å) Cite: Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities J.Med.Chem., 49, 2006

基于结构的新型过氧化物酶体增殖物激活受体（Peroxisome Proliferator-Activated Receptor, PPAR）部分激动剂家族的药物设计：虚拟筛选、X射线晶体学及体内外生物活性
描述物：3-氟-N-[1-(4-氟苯基)-3-(2-噻吩基)-1H-吡唑-5-基]苯磺酰胺、过氧化物酶体增殖物激活受体γ（PPARγ）
作者：Lu, I.L、Peng, Y.H、Huang, C.F、Lin, Y.T、Hsu, J.T.A、Wu, S.Y.
提交日期：2006年2月13日
发布日期：2006年5月16日
最后修改日期：2023年10月25日
实验方法：X射线衍射（2.54 Å）
引用文献：Structure-Based Drug Design of a Novel Family of PPARγ Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities，《J.Med.Chem.》，第49卷，2006年