PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor
收藏Protein Data Bank Japan2023-09-06 更新2026-03-21 收录
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https://pdbj.org/mine/summary/3lj3
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PI3-kinase-gamma with a pyrrolopyridine-benzofuran inhibitor Descriptor: (2Z)-4,6-dihydroxy-2-{[1-methyl-4-(4-methylpiperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]methylidene}-1-benzofuran-3(2H)-one, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION Authors: Bard, J, Svenson, K. Deposit date: 2010-01-25 Release date: 2010-04-14 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg.Med.Chem.Lett., 20, 2010
创建时间：
2010-01-25
