Effects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199096
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资源简介：
The effects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma were examined. Mouse B16F10 melanoma cells were subcutaneously injected into C57/B6 mice. When tumors were well-vascularized, mice were treated with anti-PD-1, AKT I (AZD5363)+WEE1 I (MK1775), AZD5363+MK1775+anti-PD-1, ALDH I (KS100), KS100+ anti-PD-1 daily. Mice were sacrificed when tumors in the control group (DMSO treated) reached 2000 mm3 and tumors were removed. RNA was extracted from tumor samples and gene expression was analized using RNAseq analysis. Total 6 samples were analyzed; tumors for each treatment group were pooled before RNA extraction and RNAseq analysis.
创建时间：
2023-12-31
