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Crafting pertinent policies to facilitate the high-level integration of culture and tourism has now become a vital agenda within the current discourse in China. However, relatively little is known about the actual implementation of various policies to achieve a high-level integration, especially how combinations of policy instruments are deployed in the process of realization. Based on the Policy Instrument Theory, this study uses fuzzy-set qualitative comparative analysis on a sample of 31 provincial administrative regions in China to investigate the influence of typical policy instruments on the integration level of tourism and culture. The results show that each single policy tool is not necessary for high-level integration of culture and tourism. On the contrary, only through an organic combination of different policy tools can affect the integration level. This study also summarizes five policy instrument configurations, which can be grouped into four driving modes of culture-tourism integration: the environment-driven supply-demand coordination mode, supply-driven demand-environment coordination mode, supply-driven mode, and supply-driven environment coordination mode. This study considerably provides critical theoretical and practical insights into the integration of culture and tourism from the perspective of governmental policies.