HIF1A and PPARG in cardiac hypertropthy

The genes hypoxia-inducible factor 1A and peroxisome proliferator activated receptor gamma play a role in regulating glycolysis, triacylglyceride synthesis, and ultimately hypertrophic cardiomyopathy. This diagram is derived from figure 6D in [https://pubmed.ncbi.nlm.nih.gov/19490906/ PMID 19490906]: "Schematic representation of the coregulation of glycolysis and glycerolipid synthesis by HIF1A. Hypertrophy-induced HIF1A accumulation is predicted to simultaneously promote the transcriptional upregulation of glycolytic enzymes and the direct transcriptional activation of the PPARG promoter. PPARG activity would lead to the upregulation of its target genes, GPD1 and GPAT, leading to promotion of glycerolipid biosynthesis, culminating in TAG accumulation. A secondary level of coordination is predicted to occur via the shuttling of NADH and NAD+ between GAPDH and GPD1. Thus, coordinated regulation of both these components by HIF1A is hypothesized to favor cardiomyocyte lipid accumulation in hypertrophy." This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP2456 CPTAC Assay Portal].

缺氧诱导因子1A和过氧化物酶体增殖物激活受体γ在调节糖酵解、三酰甘油合成以及最终肥厚型心肌病中发挥着重要作用。本图源自文献[https://pubmed.ncbi.nlm.nih.gov/19490906/ PMID 19490906]中的图6D：“HIF1A协同调控糖酵解和甘油酯合成的示意图。肥大诱导的HIF1A积累预计将同时促进糖酵解酶的转录上调以及PPARG启动子的直接转录激活。PPARG活性将导致其靶基因GPD1和GPAT的上调，进而促进甘油酯生物合成，最终导致三酰甘油（TAG）的积累。预计通过GAPDH和GPD1之间NADH和NAD+的穿梭，将发生二级水平的协调。因此，HIF1A对这两大组件的协同调节，被假定为有利于肥厚过程中心肌细胞的脂质积累。”该通路是[CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2456)的一部分。