Enantiospecific Total Synthesis and Absolute Configuration Assignment of Chabrolobenzoquinone H
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https://figshare.com/articles/dataset/Enantiospecific_Total_Synthesis_and_Absolute_Configuration_Assignment_of_Chabrolobenzoquinone_H/17397053
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资源简介：
Chabrolobenzoquinone H (1), a meroditerpene metabolite
with cytotoxic activity, is synthesized via a stereoselective Julia–Kocienski
olefination between a chiral pool derived aliphatic PT-sulfone and
a benzoquinone aldehyde partner. The latter was obtained via consecutive
chain extension steps involving a Stille coupling and a stereospecific
olefin cross-metathesis reaction followed by malonic ester synthesis
and a Krapcho decarboxylation. Furthermore, this total synthesis securely
determined the absolute configuration of the targeted natural product.
创建时间：
2021-12-22
