Tbk1

Enables several functions, including identical protein binding activity; protein phosphatase binding activity; and protein serine/threonine kinase activity. Involved in negative regulation of gene expression; peptidyl-serine phosphorylation; and positive regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; dendritic cell proliferation; and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain disease and frontotemporal dementia and/or amyotrophic lateral sclerosis 4. Orthologous to human TBK1 (TANK binding kinase 1). [provided by Alliance of Genome Resources, Nov 2024]

该数据集包含多种功能，包括同源蛋白结合活性、蛋白磷酸酶结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与基因表达的负调控、肽基丝氨酸磷酸化和防御反应的正调控。在包括对革兰氏阳性菌的防御反应、树突状细胞增殖和干扰素-β产生的正调控等多个过程中发挥作用。预测其位于核质中，并在细胞质中具有活性。在多个结构中表达，包括消化系统、大脑、泌尿生殖系统、呼吸系统和感觉器官。该基因的人类同源基因与脑疾病、额颞叶痴呆和/或肌萎缩侧索硬化症4有关。与人类TBK1（TANK结合激酶1）同源。[由基因组资源联盟提供，2024年11月]