Step-by-Step Strategy from Achiral Precursors to Polyoxometalates-Based Chiral Organic–Inorganic Hybrids

Using
two types of triol ligands, several novel asymmetrically triol-functionalized
Anderson organic hybrids have been efficiently synthesized in high
purity and good yields via a convenient two-step esterification reaction.
These organic–inorganic hybrids are chiral and can be spontaneously
resolved with suitable solvents. Their molecular and crystal structures
have been confirmed by single-crystal X-ray diffraction studies. Stable
solid-state chirality of the corresponding enantiopure crystals has
also been confirmed definitively by CD spectra. Interestingly, these
organic–inorganic hybrids possess a layer-by-layer structure,
forming solvent-accessible nanoscale chiral channels via a 1D infinite
helical chain substructure. TGA measurements indicated that the species
of the central heteroatoms significantly effects the stability of
these compounds.