Amino acid metabolism pathway excerpt: histidine catabolism extension

This pathway was created based on findings from the bachelor thesis project by Kristin Koppelmaa which investigated vitamin D GWAS results. Thesis DOI: https://figshare.com/articles/From_SNPs_to_Pathways_Functional_Interpretation_of_Vitamin_D_GWAS_Results/8796710. This pathway shows an excerpt of the WikiPathways amino acid metabolism (WP3925) pathway containing the segment between the metabolites histidine and glutamate that was extended. The proteins added to the conversion were AMDHD1 and UROC1. Although the HAL and FTCD proteins were included in the amino acid metabolism pathway previously, the lead SNP rs7487782 which exists in both HAL and AMDHD1, was added to the pathway and linked to these two genes. This variant was mapped to these genes during the analysis of a dataset originating from [https://www.ncbi.nlm.nih.gov/pubmed/29343764 PMID: 29343764].

本通路之构建基于Kristin Koppelmaa所进行的学士学位论文项目的研究成果，该项目对维生素D的全基因组关联研究（GWAS）结果进行了深入探讨。论文DOI：https://figshare.com/articles/From_SNPs_to_Pathways_Functional_Interpretation_of_Vitamin_D_GWAS_Results/8796710。该通路展示了WikiPathways氨基酸代谢（WP3925）通路的一部分，其中扩展了从代谢物组氨酸至谷氨酸的片段。在转化过程中新增了AMDHD1和UROC1两种蛋白质。尽管HAL和FTCD蛋白质此前已被纳入氨基酸代谢通路，但存在于HAL和AMDHD1中的主SNP rs7487782也被添加至通路中，并与这两个基因建立联系。该变异体在分析源自[https://www.ncbi.nlm.nih.gov/pubmed/29343764 PMID: 29343764]的数据集时被映射至这些基因。