Data from: Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels

The xanthone Mangostin from Garcinia mangostana was described as a potent
modulator of several potassium channels, with large-conductance K+ (BK)
channels as its primary target for vasorelaxation. The dataset compiles
electrophysiological source data for the potassium channel screen, the
characterization of Mangostin activation in BK channels, as well as the
vascular BK/β1 subunit complex and reconstituted BK-Cav nanodiomains in
whole-cell recordings. It further contains results of single-channel
recordings, the files generated in molecular docking, and the force
measurement data in native aortic tissue. These findings establish BK
channel activation as the core molecular mechanism driving Mangostin’s
vascular effects and define its structural mode of action, informing
nutraceutical safety assessment and BK-targeted drug design.