Retinal wave generation.

A previously published retinal wave model [30] was used to produce the patterns of retinal activity used in this study. Ferret retinal wave patterns served as control values. Variations from this control behavior were used to examine the sensitivity of development to particular spatiotemporal patterns of activity. The parameters , , , , and correspond to parameters of the same name as described originally [30]. RGC activity was pre-computed for each of the simulations. 24 hours of wave data was pre-computed (12 hours for short IWI and ) and this sequence of activity was repeated as many times as necessary to provide continuous patterns of retinal activity. The parameters and wave statistics for waves, particularly the extremely high wave velocity, were selected to produce correlations as reported experimentally [26].