Gut microbial dysbiosis exacerbates long-term cognitive impairment by promoting intestinal dysfunction and neuroinflammation following neonatal hypoxic ischemia. Rattus norvegicus

Neonatal hypoxic-ischemic brain damage (HIBD) is considered a major cause of long-term cognitive impairment in newborns. Researches have demonstrated that gut microbiota is associated with the prognosis of various neurological disorders. However, the role and mechanisms of microbiome-gut-brain axis on cognitive function following neonatal hypoxic-ischemia remain elusive.