Crk/CrkL morphological analysis project
收藏NIAID Data Ecosystem2026-03-12 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/DRP007050
下载链接
链接失效反馈官方服务：
资源简介：
Crk and CrkL are adapter proteins in intracellular signaling pathways that control cell-cell interactions and cell adhesion, affecting cell growth and motility. Previous study (DOI: 10.26508) reported that Crk/CrkL knockout in mouse embryos caused a variety of abnormalities in organogenesis. In mouse embryonic fibroblasts (MEFs), Crk/CrkL knockout induced abnormal cell morphology and reduced cell size. In this study, we aimed to clarify the function of Crk/CrkL in epigenetics and gene regulation. We searched for small molecule inhibitors that induce cell phenotypes similar to Crk/CrkL deficiency. We performed H3K27ac ChIP sequencing and RNA sequencing to validate the drug effects.
创建时间：
2021-03-20
