Inherited blood cancer predisposition through altered transcription elongation [ChIP-seq]
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249590
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We identified CTR9 mutants as rare heritible contributing factors to several blood cancers. We later identified partial loss of CTR9 is capable of driving key hematopoietic maintenance and self-renewal gene expression through altered transcription elongation. ChIP-seq for H3K4me3, H3K36me3, H3K79me2,MLLT3, PAF1, LEO1, CDC73, RNA polII on AAVS1 or partial CTR9 edited sorted CD34+CD45RA-CD90+ cells
创建时间：
2024-01-16
