Bold denotes measured affinity improvements, or specificity changes, greater than 3-fold. 1Improvement in binding association constant relative to wild-type (KD_mut/KD_wt). 2Specificity change toward
The 8 fentanyl derivatives and 7 fentanyl congeners are listed first and ordered by increasing binding affinity, and the 8 morphine derivatives are listed last. The green labels indicate that the mode