Enantioselective Rh-Catalyzed Carboacylation of CN Bonds via C–C Activation of Benzocyclobutenones
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Enantioselective_Rh_Catalyzed_Carboacylation_of_C_N_Bonds_via_C_C_Activation_of_Benzocyclobutenones/2089117
下载链接
链接失效反馈官方服务：
资源简介：
Herein we describe the first enantioselective
Rh-catalyzed carboacylation
of oximes (imines) via C–C activation. In this transformation,
the benzocyclobutenone C1–C2 bond is selectively activated
by a low valent rhodium catalyst and subsequently the resulting two
Rh–C bonds add across a CN bond, which provides a unique
approach to access chiral lactams. A range of polycyclic nitrogen-containing
scaffolds were obtained in good yields with excellent enantioselectivity.
Further derivatization of the lactam products led to a rapid entry
to various novel fused heterocycles.
创建时间：
2016-02-12
