The headlines produced by functional abstraction resulted in these five headline terms or functional areas (green circled red ellipses in Figure 2).

Significant GO terms are a result of over-representation analysis (ORA) of the n = 119 genes (Table 1) of the Hereditary Hearing Impairment (HHI) gene set. The precise definition of the GO terms can be obtained using AmiGO search tool for GO at http://amigo.geneontology.org/[20]. For a full list of significant terms and associated p-values, see Table S1. Remarkableness of a term is the product of the certainty that the term is not by chance associated with the GO biological process and the information of the particular subset of genes associated with the term. Genes is the number of genes annotated to the headline.