MYC-rearranged aggressive B-cell lymphoma are molecularly Burkitt Lymphoma despite of morphology [OncoScan_CNV]

Overall, the genetic profile of aggressive B-cell NHL in CAYA in the spectrum of BL and DLBCL is heterogeneous. MYC-R cases mostly displayed a molecular profile close to BL regardless of their morphology, whereas MYC-non-R had a more heterogeneous genetic landscape resembling DLBCL. Using an integrated approach, including fluorescence in situ hybridization, targeted gene Next Generation Sequencing (NGS) sequencing, copy number arrays, and gene expression profiling, we characterized 37 B-cell lymphomas in CAYA with intermediate morphological features between DLBCL and BL, blastoid morphology, DLBCL morphology with MYC rearrangements, and BL without MYC rearrangements. Please note that 'HG9_A_(OncoScan_CNV).CEL' file.(for the GSM8010850 HG9 sample) has been lost and thus is not provided.