Combined Calorie and Protein Restriction in Healthy Kidney Donors Improves Kidney Outcome in Donors and Kidney Transplant Recipients

A preoperative short-term diet combining calorie and protein restriction diet given during five days before kidney donation and transplantation improves kidney outcome in live kidney donors and kidney transplant recipients, which shows that the benefits of dietary restriction on stress resistance can be induced rapidly in humans, and may be used for clinically relevant endpoints. Gene expression differences of 3 CCPR and 5 control (n=8) male donors and 6 CCPR and 6 control (n=12) female donors were examined. Biopsies were taken during the transplantation procedure and before implantation after cold-ischemia. Making a total of n=40 samples.