Calculated mutation rates at coding microsatellites of TGFBR2 exon3 and ACVR2 exon 10 in cells with MMR deficiency.

Data from the M2 cell population from each time point between day 14 and day 35 were used for mutation rate analysis. Single mutation rates were calculated by combining and averaging time-specific mutation rates. Rates are expressed as mutations at microsatellite sequence per cell per generation. Data shown are mean��SEM. *PhMLH1?/? TGFBR2 with each of hMLH1?/? ACVR2, hMSH6?/? TGFBR2, and hMSH6?/? ACVR2. ? PhMLH1?/? ACVR2 with each of hMSH6?/? TGFBR2, and hMSH6?/? ACVR2.