BIOGRID CURATED DATA FOR MSI1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for MSI1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase

由 BioGRID (https://thebiogrid.org) 精心编纂的 MSI1（酿酒酵母 S288c）蛋白-蛋白、遗传和化学相互作用数据集；定义：染色质组装因子 I（CAF-1）的亚基；CAF-1 介导的染色质组装影响包括端粒沉默、交配型位点以及核糖体 DNA 的多种过程；维持动粒结构；DNA 修复后 DNA 损伤检查点的去激活；转录过程中的染色质动态；以及抑制非编码转录的分化；Msi1p 定位于细胞核和细胞质，并通过 Npr1p 激酶的隔离独立调节 RAS/cAMP 途径。