Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile

Co-crystal structure of the HSP90 ATP binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5- carbonitrile Descriptor: 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Heat shock protein HSP 90-alpha, PHOSPHATE ION Authors: Kung, P.-P, Sinnema, P.-J, Richardson, P, Hickey, M.J, Gajiwala, K.S, Wang, F, Huang, B, McClellan, G, Wang, J, Maegley, K, Bergqvist, S, Mehta, P.P, Kania, R. Deposit date: 2011-04-20 Release date: 2011-06-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Design strategies to target crystallographic waters applied to the Hsp90 molecular chaperone. Bioorg.Med.Chem.Lett., 21, 2011

与4-(2,4-二氯-5-甲氧基苯基)-2-甲基-7H-吡咯并[2,3-d]嘧啶-5-甲腈结合的热休克蛋白90（HSP90）ATP结合结构域的共晶体结构。描述符：4-(2,4-二氯-5-甲氧基苯基)-2-甲基-7H-吡咯并[2,3-d]嘧啶-5-甲腈、热休克蛋白HSP90-α、磷酸根离子。作者：Kung, P.-P、Sinnema, P.-J、Richardson, P、Hickey, M.J、Gajiwala, K.S、Wang, F、Huang, B、McClellan, G、Wang, J、Maegley, K、Bergqvist, S、Mehta, P.P、Kania, R。提交日期：2011-04-20；发布日期：2011-06-08；最后修改日期：2024-02-28。实验方法：X射线衍射（分辨率1.9埃）。引用文献：靶向晶体学结合水的设计策略应用于Hsp90分子伴侣。《Bioorg.Med.Chem.Lett.》，21卷，2011年。