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Enantioselective Synthesis of Coumarin Derivatives by PYBOX-DIPH-Zn(II) Complex Catalyzed Michael Reaction

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Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Enantioselective_Synthesis_of_Coumarin_Derivatives_by_PYBOX_DIPH_Zn_II_Complex_Catalyzed_Michael_Reaction/2480620
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A potential pharmacologically active chiral 3-substituted 4-hydroxy-2-oxo-2H-chromene skeleton has been synthesized by enantioselective Michael addition catalyzed by PYBOX-DIPH-Zn­(OTf)2 complex. The methodology has successfully been employed in the synthesis of (R)-Warfarin and another related compounds.
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2016-02-20
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