Data from: Sex–specific single transcript level atlas of vasopressin and its receptor (AVPR1a) in the mouse brain

Vasopressin (AVP), a nonapeptide synthesized predominantly by
magnocellular hypothalamic neurons, is conveyed to the posterior pituitary
via the pituitary stalk, where AVP is secreted into the circulation. Known
to regulate blood pressure and water homeostasis, it also modulates
diverse social behaviors, such as pair–bonding, social recognition, and
cognition in mammals, including humans. Importantly, AVP modulates social
behaviors in a sex–specific manner, perhaps due to sex differences in the
distribution in the brain of AVP and its main receptor, AVPR1a. There is a
corpus of integrative studies for the expression of AVP and AVPR1a in
various brain regions, and their functions in modulating central and
peripheral actions. In order to purposefully address sexually dimorphic
and novel roles of AVP on central and peripheral functions through its
AVPR1a, we utilized RNAscope to map Avp and Avpr1a single transcript
expression in the mouse brain. As the most comprehensive atlas of AVP and
AVPR1a in the mouse brain, this compendium highlights the importance of
newly identified AVP/AVPR1a neuronal nodes that may stimulate further
functional studies.