Gene expression profile of mouse infected by Angiostrongylus cantonensis

Infection by Angiostrongylus cantonensis accounted for the meningitis characterized by accumulation of eosinophils in non-permissive host like mouse and human. However, the underlying molecular basis is still obscure. To uncover the specific molecular mechanism responsible for the meningitis caused by Angiostrongylus cantonensis, we carried out gene expression array for mouse brain with infection by Angiostrongylus cantonensis. Four female BALB/c mice were randomly diveded into two group (2 mice each group) named control group and Angiostrongylus cantonensis (AC) infection group. For AC infection group, mice were infected with 20 stage three larvae of AC intragastrically while the mice of control group were treated by saline with the same way. All mice were raised in the specic pathogen free (SPF) environment. At 21 days post-infection, all mice were sacrificed and the whole brain tissues were used for totoal RNA extraction prior to screening by gene expression profile array.