Qingda granules lower Angiotensin-II-induced blood pressure. Qingda granules lower Angiotensin-II-induced blood pressure

The goals of this study is to compare the differently expressed genes in abdominal aorta of C57BL/6 WT mice with or without Angiotensin II (AngII) treatment as well as differently expressed genes in the abdominal aorta of WT mice with AngII treatment with or without Qingda granules (QDG) treatment. The mice (n=15) were randomly divided into 3 groups:control, AngII and QDG treated (n=5 for each group). Mice in Control and AngII groups were infused with saline or 500 ng/kg/min of AngII respectively, and orally administrated with saline; while mice in AngII + QDG group were infused with AngII (500 ng/kg/min) and orally administrated with 1.145 g/kg /day of QDG for 2 weeks. Then the abdominal aorta were used to identify differentially expressed genes among different groups. Overall design: RNA sequencing was performed with abdominal aorta of mice in 3 groups: control, AngII and QDG treated (n=5 for each group) to identify the differently expressed genes and related pathway.