Comparison of paired Wilcoxon signed-rank test results of MDAD values for shared HK genes in normal and cancer condition.

1. To characterize the discrepancy of gene expression pattern in cancer condition vs. normal condition. MD, M Distance, is defined as ; AD, A Distance, is defined as . All shared HK genes are divided into three subtypes, constant, moderate variable (Moderate), and variable.
2. Null hypothesis is the dataset coming from a distribution whose median (and mean) is zero.