Scenarios considered for simulation.

Six scenarios were considered for the computer simulations. In the scenarios A and B it is tested whether metastases do metastasize or not. In the scenarios C and D it is additionally investigated whether late disseminated tumour cells might be less capable to form metastases. To define the term “late” the size of the primary tumour/metastases is used as a benchmark. In the scenarios AR and BR the resection of the primary tumour is simulated. Again, once for the case that metastases are able to metastasise and once for the case that metastases are not able to metastasise.