Pre-eclampsia (PE) affects 5–7% of pregnancies in the US, and is a leading cause of maternal death and perinatal morbidity and mortality worldwide. To identify genes with a role in PE, we conducted a
“A”, the mutant is denoted by “B”. Tests that passed the nominal significance level of 0.1 are marked in bold. The significance level after Bonferroni correction is 0.00083. The two alleles in a SNP a
Objectives: To use a systems biology approach to integrate genotype and protein-protein interaction (PPI) data to identify disease network modules associated with chronic obstructive pul
None of the BRCA1/2 mutations demonstrated significant associations with FMR1. The single mutation noted in 10 patients was in 9 women associated with a het-norm/low FMR1 sub-genotype.