RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 soaked with CTP

RNA polymerase II elongation complex with hairpin polyamide Py-Im 1, scaffold 1 soaked with CTP Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-amino-4-[(1-methyl-4-{[1-methyl-4-({1-methyl-4-[(1-methyl-1H-imidazole-2-carbonyl)amino]-1H-imidazole-2-carbonyl}amino)-1H-pyrrole-2-carbonyl]amino}-1H-pyrrole-2-carbonyl)amino]butanoyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}propyl)(methyl)amino]propyl}carbamoyl)benzoic acid, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... Authors: Oh, J, Dervan, P.B, Wang, D. Deposit date: 2021-07-20 Release date: 2022-01-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.3 Å) Cite: RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder. Proc.Natl.Acad.Sci.USA, 119, 2022结合发夹状聚酰胺Py-Im 1、经胞苷三磷酸（CTP）浸泡的支架1的RNA聚合酶II（RNA polymerase II）延伸复合物 Descriptor: 3-({3-[(3-{[4-({4-[(4-{[4-({(2R)-2-氨基-4-[(1-甲基-4-{[1-甲基-4-({1-甲基-4-[(1-甲基-1H-咪唑-2-羰基)氨基]-1H-咪唑-2-羰基}氨基)-1H-吡咯-2-羰基]氨基}-1H-吡咯-2-羰基)氨基]丁酰}氨基)-1-甲基-1H-咪唑-2-羰基]氨基}-1-甲基-1H-吡咯-2-羰基)氨基]-1-甲基-1H-吡咯-2-羰基}氨基)-1-甲基-1H-吡咯-2-羰基]氨基}丙基)(甲基)氨基]丙基}氨基甲酰)苯甲酸，DNA指导的RNA聚合酶II亚基RPB1、DNA指导的RNA聚合酶II亚基RPB11等 作者：Oh, J, Dervan, P.B, Wang, D. 提交日期：2021-07-20 发布日期：2022-01-12 最后修改日期：2023-10-18 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率3.3 Å 引用文献：《陷入分子跑步机的RNA聚合酶II：小沟DNA结合剂引发持续转录停滞的结构基础》，《美国国家科学院院刊》（Proc.Natl.Acad.Sci.USA），第119卷，2022年