Gene expression profiling of side population (SP) cells and non-SP cells in Hodgkin Lymphoma (HL) cell lines_2

SP cells in HL cell lines are characterized by up-regulation of genes related to TNF-alpha Signaling via NF-κB, Inflammatory Response and Hypoxia compared to the non-SP cells. SP cells and non-SP cells in HL cell lines were sorted using flow cytometry, then analyzed using microarray based comprehensive gene expression in these cells to elucidate why the intracellular concentration of ROS is low in the SP compared to the non-SP.