Enantioselective Ni–Al Bimetallic Catalyzed <i>exo</i>-Selective C–H Cyclization of Imidazoles with Alkenes
收藏NIAID Data Ecosystem2026-03-10 收录
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A Ni–Al bimetallic catalyzed enantioselective C–H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with β-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol.
创建时间:
2018-04-16



