Changes in ventilatory responses at high altitude measured using rebreathing

Ventilatory responses to hypoxia and hypercapnia play a vital role in maintaining gas exchange homeostasis, and in adaptation to high-altitude environments. This study investigates the mechanisms underlying sensitization of hypoxic and hypercapnic ventilatory responses (HVR and HCVR, respectively) in individuals acclimatized to moderate high altitude (3800 m). Thirty-one participants underwent chemoreflex testing using the Duffin modified rebreathing technique. Measures were taken at sea level and after 2 days of acclimatization to high altitude. Ventilatory recruitment thresholds (VRT), HCVR-Hyperoxia, HCVR-Hypoxia, and HVR were quantified. Acclimatization to high altitude resulted in increased HVR (p<0.001) and HCVR-Hyperoxia (p<0.001), as expected. We also observed that the decrease in VRT under hypoxic test conditions significantly contributed to the elevated HVR at high altitude since the change in VRT across hyperoxic and hypoxic test conditions was greater at high altitude ..., Chemoreflex measures were collected using the Duffin modified rebreathing technique at sea level and after 2 days of acclimtization to 3800 m elevation., , # High Altitude Chemoreflex Data

[https://doi.org/10.5061/dryad.d7wm37q86](https://doi.org/10.5061/dryad.d7wm37q86)

This dataset includes supplemental figures and chemoreflex data. Chemoreflex data was collected using the Duffin modified rebreathing technique[1] in participants at sea level and after 2 days of acclimatization to 3800 m elevation. Complete methods detail is provided in the corresponding article.

## Description of the data and file structure

This is a csv file including all physiological and chemoreflex data collected in 35 participants. Chemoreflex tests were repeated in 18 participants at high altitude so some data points are paired by subject number within years at high altitude. Ventilatory volume data is raw and not BTPS corrected in this dataset as it was corrected downstream in our data analysis.

##### Variable descriptions:

* **year:** The year in which the data was collected.
* **subject:** Subject identification number.
* **condition:** The oxygen co...