Additional file 4 of Bicodon bias can determine the role of synonymous SNPs in human diseases

Table S2. Silent sSNPs. First and second columns correspond to benign sSNPs and their associated genes respectively. Each SNP affects only one codon (third SNP row), but two bicodons, when the mutation is in the P-site (first SNP row), and when the mutation is in the A-site (second SNP row), but only one codon (third SNP row). Third, fourth, fifth and sixth columns, refer to the starting bicodon, list the bicodon sequence, the p-value, the total residual score ( χ 2 = χ L 2 + χ H 2 $\chi ^{2}=\chi _{L}^{2}+ \chi _{H}^{2}$ ) and π value, respectively. The following four columns, refer to the resulting bicodon, list the bicodon sequence, the log-transformed p-value, the χ 2 score value and π value, respectively. The last three columns enumerate the relative p-value, the pause propensity variation, Δ π, and the corresponding Z-score due to the synonymous bicodon variant. (XLS 66 kb)