Diterpenoids from the Twigs and Leaves of Fokienia hodginsii

Five new isopimarane diterpenoids, fokihodgins A–E (1–5), four new labdane diterpenoids, fokihodgins F–I (6–9), and one new icetexane diterpenoid, fokihodgin J (10), as well as 18 known diterpenoids were isolated from Fokienia hodginsii. The structures of the new compounds were determined on the basis of their spectroscopic analysis, and the absolute configurations of 1 and 6 were established by X-ray crystallographic analysis. Compound 9 showed moderate cytotoxicity against HL-60 and SMMC-7721 cell lines, with IC50 values of 9.10 and 7.50 μM, respectively.